Photo by ROBIN WORRALL on Unsplash


For tutorials on physiology and treatment of acute and chronic pain please sign up on the Tutorial/Seminar Booking System website. The venue for the tutorial this term will be "The Hubb" at the Kellogg college (see the yellow square on the map below/left). There is a direct access from Banbury road rather through the college.

I would appreciate if you could give me feedback after the tutorial by answering this short survey.

Links to suggested reading materials:

    Pain and nociception:
  1. Seymour, Ben. 2019. Pain: A Precision Signal for Reinforcement Learning and Control Neuron 101(6):1029-1041.
  2. McDermott, Lucy et al. 2019. Defining the Functional Role of NaV1.7 in Human Nociception Neuron 101(5):905-919.
  3. Arcourt, Alice et al. 2017. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron 93(1):179–93.
  4. McDermott, Lucy et al. 2019. Defining the Functional Role of NaV1.7 in Human Nociception. Neuron. 101:905-919.
  5. Ploner, Marcus et al. 2010. Prestimulus Functional Connectivity Determines Pain Perception in Humans. Proceedings of the National Academy of Sciences 107(1):355–60.
  6. Abbadie, Catherine. 2005. Chemokines, chemokine receptors and pain. Trends in Immunology. 26:529–534.
  7. Arcourt, Alice et al. 2017. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron 93:179–193.
  8. Gomtsian, Lusine et al. 2018. Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain. Pain. 159:2512–2521.
  9. Gunner, Georgia et al. 2019. Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nature Neurosci. 22:1075–1088.
  10. Fritz, Michael et al. 2016. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. Journal of Clinical Investigation. 126:695–705.
  11. Basbaum Allan et al. 2009. Cellular and Molecular Mechanisms of Pain. Cell. 139:267-284
  12. Price Donald D. 2000 Psychological and neural mechanisms of the affective dimension of pain. Science. 288:1769-72.
  13. Joachim Scholz and Clifford J. Woolf. 2002 Can we conquer pain? Nature Neuroscience. 5:1062-1067
  14. Melzack Ronald. 2001. Pain and the neuromatrix in the brain. J Dent Educ 265:1378–82.
  15. Salomons, Tim et al. 2016. The ‘pain matrix’ in pain-free individuals. JAMA Neurology. 73:755–756.

    Central sensitisation:
  1. Woolf, Clifford J. 2011. Central Sensitization: Implications for the Diagnosis and Treatment of Pain. Pain 152(Suppl.3):S2–15.
  2. Ji, Ru Rong et al. 2003. Central sensitization and LTP: Do pain and memory share similar mechanisms? Trends Neurosci. 26:696–705.

    Chronic pain and pain mechanisms:
  1. Kosek, Eva et al. 2016. Do we need a third mechanistic descriptor for chronic pain states? Pain 157:1382–1386
  2. Borsook, David et al. 2018. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 159:2421-2436.
  3. Borsook, David and Kalso, Eija A. 2015. Transforming Pain Medicine: Adapting to Science and Society. Eur J Pain 25(8):713–24.
  4. Yezierski, Robert and Hansson, Per 2018. Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong? The Journal of Pain 19:571-588.
  5. Grace, Peter M et al. 2014. Pathological pain and the neuroimmune interface. Nature Reviews Immunology 14:217-231.
  6. Suzuki, Rie et al. 2004. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends in Pharmacological Sciences. 25:613-617.
  7. Flor, Herta et al. 2006. Phantom Limb Pain: A Case of Maladaptive CNS Plasticity? Nature Reviews Neuroscience 7(11):873–81.
  8. Falk, Sarah and Dickenson, Anthony H 2014 Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain. Journal of Clinical Oncology 32:1647-1654.
  9. Mantyh, Patrick W. et al. 2002. Molecular Mechanisms of Cancer Pain. Nat Rev Cancer. 2:201–209.
  10. Knowles, Charles and Qasim, Aziz. 2009 Basic and clinical aspects of gastrointestinal pain. Pain. 141:191-209.
  11. Buse, Dawn et al. 2019. Migraine Progression: A Systematic Review. Headache: The Journal of Head and Face Pain 59:306-338.
  12. Fejes, Eva et al. 2020. Characteristics of Patients Referred To A Specialized Headache Clinic. Scientific Reports 10:1146.
  13. Schaible, Hans-Georg 2012. Mechanisms of Chronic Pain in Osteoarthritis. Current Rheumatology Reports. 14:549–556
  14. Brito, Renan et al. 2017. Regular physical activity prevents development of chronic muscle pain through modulation of supraspinal opioid and serotonergic mechanisms. PAIN Reports. 2:e618.

    Impact of chronic pain:
  1. Leadley, Regina et al. 2012 Chronic diseases in the European union: the prevalence and health cost implications of chronic pain. J Pain Palliat Care Pharmacother. 26:310–25.
  2. Faya, Alan et al. 2016. Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies. BMJ Open.6:e010364.
  3. Mäntyselkä, Pekka et al. 2003. Chronic pain and poor self-rated health. JAMA. 290:2435.
    Animal studies:
  1. Klinck, Mary et al. 2017. Translational Pain Assessment: Could Natural Animal Models Be the Missing Link? Pain 158(9):1633–46.
  2. Mogil, Jeffrey. 2009. Animal Models of Pain: Progress and Challenges. Nature Reviews Neuroscience. 10:283–294.

  1. Colvin, Lesley and Rice, Andrew. 2019. Progress in pain medicine: where are we now? British Journal of Anaesthesia. 23:e173–e176.
  2. Gilron, Ian et al. 2013. Combination pharmacotherapy for management of chronic pain: from bench to bedside. The Lancet Neurology 12:1084-1095.
  3. Woolf, Clifford 2010. Overcoming obstacles to developing new analgesics. Nature Medicine. 16:1241–1247.
  4. Dickenson, Anthony et al. 2002 Neurobiology of neuropathic pain: mode of action of anticonvulsants. European Journal of Pain. 6 Suppl A:51-60.
  5. Brown, Mark et al. 2013 Tanezumab Reduces Osteoarthritic Hip Pain: Results of a Randomized, Double‐Blind, Placebo‐Controlled Phase III Trial. Arthritis and Rheumatology. 65:1795-1803.
  6. Bruno, T Saragiotto et al. 2019. Paracetamol for pain in adults. BMJ. 367:l6693
  7. Jóźwiak-Bebenista, Marta and Nowak, Jerzy. 2014. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 71:11-23.
  8. Machado, Gustavo et al. 2019. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ 350:h1225–h1225.
  9. Williams, Christopher M. et al. 2014. Efficacy of Paracetamol for Acute Low-Back Pain: A Double-Blind, Randomised Controlled Trial. The Lancet 384(9954):1586–96.
  10. Moore, Andrew R et al. 2015. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions European Journal of Pain. 19:1213-23
  11. Leopoldino, Amanda 2019. Paracetamol versus placebo for knee and hip osteoarthritis. Cochrane Systematic Review.
  12. Chaparro, Luis Enrique et al. 2007. Opioids for chronic low-back pain. Cochrane Database Syst Rev
  13. Nüesch, Eveline et al. 2009. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev.
  14. Eisenberg, Evan et al. 2006. Opioids for neuropathic pain. Cochrane Database Syst Rev.
  15. Noble, Meredith et al. 2010. Long-term opioid management for chronic noncancer pain. Cochrane Database Syst Rev.

  1. Schafer, Scott M et al. 2018 Mechanisms of placebo analgesia: A dual-process model informed by insights from cross-species comparisons. Progress in Neurobiology 160:101-122.
  2. Goetzche, Peter. 1994. Is there logic in the placebo? The Lancet. 344:P925-926.
  3. Enck, Paul et al. 2008 New insights into the placebo and nocebo responses. Neuron. 31:195-206

  1. Thompson, Trevor et al. 2017. Analgesic Effects of Alcohol: A Systematic Review and Meta-Analysis of Controlled Experimental Studies in Healthy Participants Journal of Pain. 18:499-510.
  2. Yamada, Akihiro et al. 2018. Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa. Molecular Pain. 14:1–13

    Patient perspective:
  1. Courtney, Carol A. et al. 2017. Frida Kahlo: Portrait of Chronic Pain Physical Therapy;97:90–96
  2. Mantel, Hilary. 2013. ‘How Much Pain Is Too Much Pain?’ IASP Insight (July):8–12.

    An overview of my research (for those interested):
  1. Wartolowska, Karolina 2011. How neuroimaging can help us to visualise and quantify pain? European Journal of Pain Supplements 5: 323–327
  2. Wartolowska, Karolina and Tracey, Irene. 2010. - a book chapter in Imaging in CNS Drug Discovery and Development page 251